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Conditions of optimal human M-CSF R / CSF1R / CD115 protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Source: recombinant human M-CSF R / CSF1R / CD115 protein (Ile 20 - Glu 512) was expressed in mammalian cells with a His and Avi tag at the C-terminus.
Accession: P07333
Predicted molecular mass: 57.4 kDa. Due to glycosylation, the recombinant human M-CSF R / CSF1R / CD115 protein migrates to 75-105 kDa based on the Bis-Tris PAGE result.
Endotoxin: Less than 1 EU per ug by the LAL method.
Formulation: The recombinant human M-CSF R / CSF1R / CD115 protein was lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Purity: > 95% by SDS-PAGE and HPLC.
Shipping: The recombinant human M-CSF R / CSF1R / CD115 protein is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Background
CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
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