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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal human LILRB4 / CD85k / ILT3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Source: recombinant human LILRB4 / CD85k / ILT3 protein (Gln 22 - Glu 259) was expressed in mammalian cells with a His tag and Avi at the C-terminus.
Accession: AAH26309
Predicted molecular mass: 28.6 kDa. Due to glycosylation, the recombinant human LILRB4 / CD85k / ILT3 protein migrates to 38-42 kDa based on the Bis-Tris PAGE result.
Endotoxin: Less than 1 EU per ug by the LAL method.
Formulation: The recombinant human LILRB4 / CD85k / ILT3 protein was lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Purity: > 95% by SDS-PAGE and HPLC.
Shipping: The recombinant human LILRB4 / CD85k / ILT3 protein is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Background
LILRB4,also known as CD85k and LIR-5, ILT3, is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation. Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).LILRB4 is receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
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