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Human IL-10 Protein

Interleukin-10, IL-10, CSIF

Catalog No. Product Name Size List Price (US$) Quantity
Description

BP003079: Recombinant Human IL-10-His-Avi Protein (rhIL10-His)

Source: recombinant human IL-10 protein (Ser 19 - Asn 178) was expressed in mammalian cells with a His tag and Avi at the C-terminus.
Accession: P22301
Predicted molecular mass: 21.3 kDa. Due to glycosylation, the recombinant human IL-10 protein migrates to 23-25 kDa based on the Bis-Tris PAGE result.
Endotoxin: Less than 1 EU per ug by the LAL method.
Formulation: The recombinant human IL-10-His-Avi protein was lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Purity: > 95% by SDS-PAGE and HPLC.

Shipping: The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Background

Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life.

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