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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal Granzyme M Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Granzyme M, also known as Met-1 serine protease, Met-ase, Natural killer cell granular protease, MET1 and GZMM, is a secreted protein which belongs to the peptidase S1 family of Granzyme subfamily. Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, granzyme M. GZMM contains one peptidase S1 domain and is highly, constitutively expressed in activated natural killer (NK) cells. GZMM cleaves peptide substrates after methionine, leucine, and norleucine. Its physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. GZMM promotes caspase activation and subsequent apoptosis of target cells.
BP001416-C965: Recombinant Human Human Granzyme M/GZMM (Met-1 serine protease)
Source: HEK 293 derived.
Purity > 95%, by reducing SDS-PAGE and SEC-HPLC.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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