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Background Information:
GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) with IC50 of 10 nM. It does not suppress activity on other 96 kinases, including Aurora, ROCK, p38 MAPK and PI3K. GSK2334470 has been used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt.
Reference:
1. Najafov, et al., Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem.J. (2011), 433 (2) 357.
APIM050166: GSK2334470
CAS No.: 1227911-45-6.
Molecular Formula: C25H34N8O ? 0.3H2O.
Molecular Weight: 468.
Purity: 99.9-100% by achiral and chiral HPLCs at 214 and 254 nm. [α]20D = - 32.6 o (c 1.17, MeOH).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis Report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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