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Background Information:
GSK1120212 is a potent, highly selective and orally active inhibitor of MEK 1/2 inhibitor in clinical trial.
Reference:
1. Gilmartin AG, Bleam MR, Groy A, Moss KG, et al., GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition, Clin Cancer Res. 2011 Jan 18. [Epub ahead of print].
APIM050162: GSK1120212 (TRAMETINIB)
CAS No.: 871700-17-3.
Molecular Formula: C26H23FIN5O4.
Molecular Weight: 615.39.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: MS, 1HNMR, HPLC, and quantitative elemental analysis report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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