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Conditions of optimal GNMT Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cause of hypermethioninemia. the patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
BP000931-CE34: Recombinant Human Glycine N-methyltransferase (GNMT) Enzyme
Source: E. coli-derived.
Recombinant Human Glycine N-methyltransferase (GNMT) Enzyme is expressed with sequence (Val2-Asg294) of Human GNMT fused with a 6His tag at both the N-terminus and at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Formulation: 0.2 um filtered solution in 20 mM TrisHCl, 150 mM NaCl, pH 8.0.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: 0.2 um filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other GNMT Enzymes:
Recombinant Human GNMT Enzyme
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