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Conditions of optimal GluR2 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
GLUR2, also called Glutamate receptors and mediated by a G-protein that inhibits adenylate cyclase activity, sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA), are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. GLUR2? cytogenetic location is 4q32.1. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. As previously demonstrated in rats, the GLUR2 in human has RNA editing, posttranscriptional change of the sequence at the mRNA level. And interruption of the interaction between C-terminal Glur2 and PDZ domain-containing proteins, such as GRIP and PICK1, resulted in increased AMPA receptor-mediated excitatory transmission and blockade of long-term depression.GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse.
PA001778-PA1598: GLUR2 Polyclonal Antibody
Rabbit Polyclonal Antibody;
Applications: WB: 0.1-0.5 ug/ml IHC: 0.5-1 ug/ml.
Reactivity: Human, Rat, Mouse.
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human GLUR2, identical to the related rat and mouse sequences.
Purification: Immunogen affinity purified.
Form of Atibody: Lyophilized.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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