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Conditions of optimal GHR antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
The GHR locus to human chromosome 5p13.1-p12 and to mouse chromosome 15.1 Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb.2 GHR consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are 2 isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3 (d3GHR). Furthermore,the two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing.In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the GHR gene have been demonstrated as the cause of Laron syndrome , also known as the growth hormone insensitivity syndrome (GHIS).
PA000188-PA1726: GHR Polyclonal Antibody
Rabbit Polyclonal Antibody.
Reconstitution: 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Application: WB: 0.1-0.5 ug/ml.
Reactivity: Mouse, Rat.
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of mouse GHR, identical to the related rat sequence.
Purification: Immunogen affinity purified.
Form of Atibody: Lyophilized.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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