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Background Information:
GDC-0449 (Vismodegib) is an orally-administered small molecule inhibitor of Hedgehog signaling pathway.
Reference:
1. Amini S, Viera MH, Valins W, Berman B. Nonsurgical innovations in the treatment of nonmelanoma skin cancer. J Clin Aesthet Dermatol. 2010 Jun;3(6):20-34.
2. So PL, Tang JY, Epstein EH. Novel investigational drugs for basal cell carcinoma. Expert Opin Investig Drugs. 2010 Sep;19(9):1099-112.
3. De Smaele E, Ferretti E, Gulino A. Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers. Curr Opin Investig Drugs. 2010 Jun;11(6):707-18.
APIM050352: GDC-0449 (VISMODEGIB)
CAS No.: 879085-55-9.
Molecular Formula: C19H14Cl2N2O3S.
Molecular Weight: 421.3.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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