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Background Information:
GDC-0068 is a potent, APT-competitive and orally available small molecule pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively, and with selectivity over more than other 200 screened kinases. It displays robust antitumor activity with activated PI3K-Akt-mTOR pathway, and is currently in clinical trials.
APIM050149: GDC-0068
CAS No.: 1001264-89-6.
Molecular Formula: C24H32ClN5O2?1.6HCl.
Molecular Weight: 520.
Purity: 99% chem and stereomeric purity (HPLC and Chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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