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Conditions of optimal GAD67 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
Glutamic acid decarboxylase (GAD) catalyses the conversion of L-glutamic acid to the inhibitory eurotransmitter gamma-aminobutyric acid (GABA). Two forms of human GAD, GAD65 and GAD67, re encoded by two separate genes. Human GAD65 cDNA encodes a Mr 65,000 polypeptide, with 85 amino acid residues, whereas human GAD67 encodes a Mr 67,000 polypeptide, with 594 amino cid residues. GAD67 gene consists of 16 exons, spread over more than 45 kb of genomic DNA. The AD67 gene contains an additional exon (exon 0) that together with part of exon 1, specifies the 5' ntranslated region of GAD67 mRNA. Human GAD67 shows 65% identity to GAD65 and is located in q31. GAD67 may play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to ead to pyridoxine dependency with seizures.
PA000523-PA1036: GAD67 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: Human, mouse, rat. No cross reactivity with other roteins.
Applications: Western blot: At 1-2ug/ml with the appropriate system to detect GAD67 in cells and tissues. Immunohistochemistry(P): At 1-2ug/ml to detect GAD67 in formalin fixed and paraffin embedded tissues.
Reactivity: Human, Mouse, Rat.
Immunogen: A peptide mapping very near the N-terminal end of GAD67 of human rigin, identical to the related mouse sequence.
Purification: Immunogen affinity purified.
Form of Antibody: Each vial contains 50% glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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