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Conditions of optimal Frizzled-7 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Frizzled-7 is a member of the Frizzled family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, it leads to the activation of disheveled proteins, nuclear accumulation of beta-catenin, inhibition of GSK-3 kinase and activation of Wnt target genes. Frizzled-7 is a unconventional G-protein-coupled glycoprotein receptors for Wnt proteins. Frizzled-7 contains a divergent N-terminal signal peptide,a conservedcysteine-rich domain, avariable-length linker region,a seven-pass transmembrane region, and a variable-length C-terminal cytoplasmic domain. Frizzled-7 is expressed in skeletal muscle to mediate muscle regeneration in response to Wnt-7a. It also expressed in embryonic stem cells, contributing to self renewal signaling.
BP001507-C413: Recombinant Frizzled-7 (FZD7) Protein
Source: HEK 293-derived.
Recombinant Frizzled-7 (FZD7) Protein is expressed with sequence (M1-L185) of Human Frizzled-7 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 EU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB,150 mM NaCl, Ph 7.2.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
FZD7 Antibodies:
FZD7 Polyclonal Antibody
FZD7 Polyclonal Antibody
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