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Background Information:
FRAX486 is an orally bioavailable and Blood-Brain Barrier (BBB) penetrable small molecule PAK (p21-activated kinase) inhibitor with IC50 values of 14, 33, 39 and 500 nM for PAK1, PAK2, PAK3 and PAK4, respectively.
Reference:
1.B. M. Dolan, et al, Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486, PNAS, 2013, No 14, Vol 110 pp5671-5676
APIM050147: FRAX486
CAS No.: 1232030-35-1.
Molecular Formula: C25H23Cl2FN6O ? ½(H2O).
Molecular Weight: 522.4.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Microanalysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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