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Background Information:
EPZ-5676 (Pinometostat) is a potent, selective and S-adenosyl methionine (SAM) competitive inhibitor of DOT1L methyltransferase (Ki = 80 pM), displaying 37,000-fold selectivity over all other methyltransferases tested. It inhibits H3K79 methylation and MLL-fusion target gene expression, and potently and selectively kills acute leukemia cell lines bearing MLL translocations. It is currently in clinical trials.
APIM050327: EPZ-5676 (PINOMETOSTAT)
CAS No.: 1380288-87-8.
Molecular Formula: C30H42N8O3• 0.5HCl.
Molecular Weight: 580.9.
Purity: ≥99% (HPLC at 214 and 254 nm), ≥99.5% Stereomerical Purity (Chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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