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Background Information:
Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent.
Reference:
1. Luk SU, Yap WN, Chiu YT, Lee DT, Ma S, Lee TK, Vasireddy RS, Wong YC, Ching YP, Nelson C, Yap YL, Ling MT. Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. Int J Cancer. 2010 Jul 8. [Epub ahead of print] PubMed PMID: 20617516.
2. Lorusso P, Shields AF, Gadgeel S, Vaishampayan U, Guthrie T, Puchalski T, Xu J, Liu Q. Cediranib in combination with various anticancer regimens: results of a phase I multi-cohort study. Invest New Drugs. 2010 Jul 6. [Epub ahead of print] PubMed PMID: 20607586.
3. Zeng ZL, Wu MW, Sun J, Sun YL, Cai YC, Huang YJ, Xian LJ. Effects of the Biological Clock Gene Bmal1 on Tumor Growth and Anticancer Drug Activity. J Biochem. 2010 Jun 23. [Epub ahead of print] PubMed PMID: 20576619.
APIM050298: DOCETAXEL
CAS No.: 114977-28-5.
Molecular Formula: C43H55NO14.
Molecular Weight: 807.9.
Purity: >99.5% (by HPLC).
QC: HPLC, NMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, Alcohols, Acetone, insoluble in water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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