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Background Information:
An orally-active inhibitor of Aurora kinases A and B, and VEGFR2, currently in clinical trial for cancer treatment.
Reference:
1. Wang, Shudong; Midgley, Carol A.; Scaerou, Frederic; Grabarek, Joanna B.; Griffiths, Gary; Jackson, Wayne; Kontopidis, George; McClue, Steven J.; McInnes, Campbell; Meades, Christopher; Mezna, Mokdad; Plater, Andy; Stuart, Iain; Thomas, Mark P.; Wood, Gavin; Clarke, Rosemary G.; Blake, David G.; Zheleva, Daniella I.; Lane, David P.; Jackson, Robert C.; Glover, David M.; Fischer, Peter M. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors. Journal of Medicinal Chemistry (2010), 53(11), 4367-4378.
2. MacCallum, David; Green, Simon. Combination of CNDAC with a 2-substituted-4-heteroaryl-pyrimidine amine and use thereof in the treatment of a proliferative disorder. PCT Int. Appl. (2007), 48pp. CODEN: PIXXD2 WO 2007132228 A1 20071122 CAN 147:534652 AN 2007:1333052 .
APIM050133: CYC-116
CAS No.: 693228-63-6.
Molecular Formula: C18H20N6OS.
Molecular Weight: 368.5.
Purity: > 99% (HPLC).
QC: 1HNMR, HPLC.
Solubility: Soluble in DMSO and Ethanol.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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