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Background Information:
CO-1686 is an orally bioavailable, irreversible EGFR inhibitor, selectively targeting EGFRL858R/T790M mutant with a Ki value of 21 nM over Wt EGFR (Ki = 303 nM), currently in clinical evaluation for NSCLC treatment.
Reference:
1. A. O. Walter, et al, Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC, Cancer Discov., 2013 Dec; 3(12):1404-15.
APIM050131: CO-1686 (ROCILETINIB)
CAS No.: 1374640-70-6.
Molecular Formula: C27H28F3N7O3.
Molecular Weight: 555.6.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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