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Background Information:
CNDAC (DFP-10917) is an orally available deoxycytosine nucleoside analog with potential antineoplastic activity. Upon administration, CNDAC (DFP-10917) is phosphorylated to generate its nucleotide form, functioning as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, resulting in G2/M phase-arrest and tumor cell apoptosis. It is currently under clinical evaluation to treat haematological malignancies.
APIM050297: CNDAC (DFP-10917, TAS-109)
CAS No.: 134665-72-8 (HCl salt) 135598-68-4 (free base).
Molecular Formula: C10H12N4O4?HCl.
Molecular Weight: 288.7.
Purity: 99.9% chem and optical purity.
QC: Achiral and Chiral HPLCs, 1H- and NOESY NMRs, Elemental Analysis Report.
Solubility: Refer to Certificate.
Storage: Refer to Certificate.
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