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Background Information:
CH5424802 is a potent, selective and orally bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitor (IC50 = 1.9 nM) capable of blocking the resistant gatekeeper mutant.
Reference:
1. H. Sakamoto, et al., Cancer Cell, Volume 19, Issue 5, p679-690.
2. K. Kinoshita, et al., Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor. Bioorganic & Medicinal Chemistry, Vol. 20, Issue 3, 1 February 2012, Pages 1271-1280.
APIM050130: CH5424802
CAS No.: 1256580-46-7.
Molecular Formula: C30H34N4O2?0.5HCl?0.5H2O.
Molecular Weight: 509.9.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: In DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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