Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
2′,3′-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is the endogenous agonist for the STING (STimulator of INterferon Genes), a receptor crucial to activate the innate immune system. It is a noncanonical cyclic dinucleotide (CDN) produced as a second messenger in mammalian cells by the cytosolic cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. The binding potency of noncanonical 2′,3′-cGAMP for human STING is much better than that of the canonical 3′,3′-cyclic dinucleotides (CDNs) produced in bacterial, with a Kd of 4.6 nM compared to >1 μM for bacterial 3′,3′-CDNs (refs 1-3).
Reference:
1. Zhang X. et al., 2013. Cyclic GMP-AMP containing mixed phosphdiester linkages is an endogenous high-affinity ligand for STING. Mol Cell.51(2):226-35.
2. Diner E. et al., 2013. The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING. Cell Rep. 3(5):1355-61.
3. Gao P. et al., 2013. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 153(5):1094-107.
APIM050001: CGAMP, SODIUM SALT
CAS No.: 1441190-66-4.
Molecular Formula: C20H22N10O13P2 ·2Na.
Molecular Weight: 718.4. About 1 mg powder equals to 1.39 µmol.
Purity: >99.5% by HPLC, snow-white, disodium salt. in vivo grade material.
QC: HPLC, MS, 1H-, 31P- NMRs.
Solubility: Water, >50 mM.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.