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Background Information:
CEP-28122 mesylate is a highly potent, selective and orally active ALK inhibitor (Ezymatic IC50: 1.9 nM (ref 1), 3 nM (ref 2), Cellular IC50: 30 nM (ref 2), Cellular IC50 in 75% murine: 300 nM (ref 2)), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK-positive human cancer cells and tumor xenograft models in mice.
APIM050127: CEP-28122 MESYLATE
CAS No.: 1354545-57-5.
Molecular Formula: C28H35ClN6O3 ? 1.6CH4O3S.
Molecular Weight: 692.8.
Purity: 100% optical purity (Chiral HPLC), >99% purity (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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