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Introduction
Fc fragment of IgA receptor (FCAR) also known as CD89 (Cluster of Differentiation 89), is a human gene. This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.
PA000288-010007C01: CD89 (Fc?RI) Monoclonal Antibody
Mouse Monoclonal Antibody.
Specificity/Sensitivity: Anti-human CD89 (FcaRI), recognising the EC1 domain of the FcaRI extracellular region.
Applications: Flow cytometry.
Reactivity: Human.
Immunogen: Soluble CD89.
Form of Antibody: 1 ug/ml in PBS containing 0.1% sodium azide as a preservative.
Clone No: MIP7c.
Isotype: Mouse IgG1.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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