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Conditions of optimal CD73 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction:
CD73, also known as NT5E, NTE, is a glycosyl phosphatidylinositol (GPI) anchored membrane protein which belongs to the 5'-nucleotidase family. CD73 is an ecto 5'-Nucleotidase expressed by most cell types. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. CD73 is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. CD73 is a lymphocyte maturation marker that has functions independent of its catalytic activity. CD73 is also a regulator of leukocyte extravasation, a function that requires its 5'Nucleotidase activity. Defects in NT5E are the cause of calcification of joints and arteries (CAJA).The recombinant CD73 lacking GPI anchor is secreted as a monomer.
BP001182-C446: Recombinant Human CD73 Enzyme
Source: HEK 293-derived.
Recombinant Human CD73 Enzyme is expressed with sequence (Trp27-Lys547) of Human NT5E fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 EU/ug).
Formulation: 0.2 um filtered solution in Tris, NaCl, CaCl2 and Glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
CD73 Antibodies:
CD73 Monoclonal Antibody
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