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Background Information:
BMS-911543 is a potent, selective and orally active inhibitor of JAK2 (Ki = 0.48 nM), highly selective over JAK1 (Ki = 1117 nM) and JAK3 (Ki = 357 nM). It is currently in clinical trials.
Reference:
1. A. V. Purandare, et al., Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2, Leukemia, 26(2), 280-8 (Feb. 2012 ).
APIM050120: BMS-911543
CAS No.: 1271022-90-2.
Molecular Formula: C23H28N8O.
Molecular Weight: 432.5.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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