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Background Information:
A highly potent (IC50 0.8 nM), selective (>10,000 selectivity over other kinases) and ATP-competitive inhibitor of polo-like kinase 1 (PLK1), a key regulator of mitotic progression.
Reference:
1. Steegmaier, M., et al, BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo. Curr Biol, 17, 316-322 (2007).
2. Lénárt, P., et al., The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol, 17(4), 304-15 (2007).
APIM050113: BI 2536
CAS No.: 755038-02-9.
Molecular Formula: C28H39N7O3?H2O.
Molecular Weight: 539.66.
Purity: 99% chem and optical purity (HPLC, Chiral HPLC at 214 and 254 nm).
QC: LC/MS, 1HNMR, Chiral HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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