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Background Information:
Bexarotene is a synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. It selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression.
Reference:
1. Galper SL, Smith BD, Wilson LD. Diagnosis and management of mycosis fungoides. Oncology (Williston Park). 2010 May; 24(6):491-501.
2. Trufant JW, Kreizenbeck GM, Carlson KR, Muthusamy V, Girardi M, Bosenberg MW. A transient epidermolysis bullosa simplex-like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote. J Cutan Pathol. 2010 May 17. [Epub ahead of print].
APIM050355: BEXAROTENE
CAS No.: 153559-49-0.
Molecular Formula: C24H28O2.
Molecular Weight: 348.48.
Purity: >99% (HPLC).
QC: 1HNMR, HPLC and MS.
Solubility: Soluble in DMSO, Alcohols, Common Organic Solvents.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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