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BD-2 Protein

β-defensin 2, hBD-2, Defensin, Beta 2, Skin-Antimicrobial Peptide 1, SA,P1 DEFB4A, DEFB102, DEFB2, DEFB4, DEFB4B

Catalog No. Product Name Size List Price (US$) Quantity
BP000062-C127 Recombinant Human BD-2 Protein 10 ug 98.00
BP000062-C127 Recombinant Human BD-2 Protein 50 ug 264.00
BP000062-C127 Recombinant Human BD-2 Protein 1 mg 2640.00
Description

Introduction
The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.
Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells.
Beta-defensin 1 may play a role in the pathogenesis of severe sepsis. Variation in human Beta Defensin-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human Beta Defensin-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. The expression of Human BD1 is correlated with induction profiles in gingival keratinocytes. The level of expression of human DEFB1 mRNA is lower than that of human BD3 and human BD-2 in reconstructed epidermis.

BP000061-C127: Recombinant Human Beta-Defensin 2 (BD-2) Protein

Source: E. coli-derived.
Recombinant Human Beta-Defensin 2 (BD-2) Protein is expressed with sequence (Gly24-Pro64) of Human β-Defensin 4A.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 130 mM NaCl, pH 7.4.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other BD-2 Proteins:
Recombinant Human BD-2 Protein

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