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Background Information:
BAY 1895344 is an orally available, potent and selective ATR inhibitor with an in vitro IC 50 of 7nM. It potently inhibits the proliferations of a broad spectrum of human tumor cell lines (cellular media IC50 = 78 nM), and exhibits strong in vivo anti-tumor efficacy in both mono- and combination therapy in a variety of xenograft models. It is currently in clinical evaluation.
APIM050110: BAY-1895344 (BAY1895344)
CAS No.: 1876467-74-1 (Free Base).
Molecular Formula: C20H21N7O.
Molecular Weight: 375.4.
Purity: 99.9% by achiral and chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, 1H-NMR and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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