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Background Information:
AZD8055 is a potent, orally bioavailable and ATP-competitive mTORC1/C2 inhibitor with an IC50 of 0.8 nM, highly selective ( ~1000 fold) over all class I PI3K isoforms and other PI3K-like kinase family, and there is no significant activity against a panel of other 260 kinases at a concentration up to 10,000 nM.
Reference:
1. C. M. Chresta, et al, AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity, Cancer Res. 2010, 70: 288-298.
APIM050103: AZD8055
CAS No.: 1009298-09-2.
Molecular Formula: C25H31N5O4.
Molecular Weight: 465.5.
Purity: 99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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