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Background Information:
AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor with IC50s at 5 nM and <10 nM for CHK1 and CHK2, respectively, currently in clinical trials.
Reference:
1. S. Ashwell , et al., DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.
2. SD Zabludoff, et al., AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008, 7(9), 2955-2966.
3. L Carrassa, et al., Role of Chk1 in the differentiation program of hematopoietic stem cells. Cell. Mol. Life Sci. 2010, 67, 1713–1722.
APIM050102: AZD7762
CAS No.: 860352-01-8.
Molecular Formula: C17H19FN4O2S •HCl •H2O.
Molecular Weight: 416.9.
Purity: >99.5% chem and optical purity (HPLC and chiral HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, Chiral HPLC and Quantitative Elemental Analysis.
Solubility: In DMSO, water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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