Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
AZD5582 is a cell permeable, novel class of dimeric SMAC mimetic designed to mimick the AVPI motif of SMAC. It is a potent and selective inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein with IC50 values of 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2, respectively. At nanomolar concentrations AZD5582 causes extensive degradation of cIAP-1 and cIAP-2, and induces apoptosis in MDA-MB-231 breast cancer cells. It causes substantial tumor regressions following two weekly doses of 3.0 mg/kg in MDA-MB-231 xenograft-bearing mice.
Reference:
1.E.J. Hennessy, et al, Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582), J. Med. Chem., 2013, 56 (24), pp 9897–9919.
APIM050294: AZD5582
CAS No.: 1258392-53-8.
Molecular Formula: C58H78N8O8 ? 2HCl ? 2.5H2O.
Molecular Weight: 1133.3.
Purity: ≥99% purity (HPLC).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, Water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.