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Background Information:
AZD5363 is an orally bioavailable, selective and potent inhibitor of all PKB/AKT iso-forms with a potency of 10 nM or less(Ref 1).
Reference:
1. B. R. Davies, et al., Preclinical Pharmacology of AZD5363, an Orally Bioavailable Inhibitor of AKT: Pharmacodynamics, Antitumor Activity and Correlation of Monotherapy Activity with Genetic Background. Mol. Cancer Ther. 2012, 11(4), 873-887.
APIM050099: AZD5363
CAS No.: 1143532-39-1.
Molecular Formula: C21H25ClN6O2.
Molecular Weight: 428.9.
Purity: >99% chem and optical purity (HPLC and Chiral HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: In DMSO, water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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