Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Catalog No. | Product Name | Size | List Price (US$) | Quantity |
---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
AZD4320 (AZD-4320) is a BH3 mimetic and highly potent dual Bcl-2/Bcl-XL inhibitor with binding affinity in low nanomolar range similar to ABT-263 (Novitoclax), but with a better therapeutic index (lower toxicities) and amenable to I. V. administration (ref 1). It rapidly induces caspase-3 (CC3) cleavage and cell death in both Bcl-2-driven (SuDHL4, GI50 <50 nM) and Bcl-XL-driven (SuDHL8, GI50 <50 nM) diffuse large B-cell lymphoma (DLBCL) cell lines; Achieves complete and sustained (>24 days) tumor regressions in a mouse RS4;11 acute lymphocytic leukemia xenograft model (20 mg/kg, i.v.) (ref 1).
Reference:
1. J. Cidado, et al, AZD4320 is a potent, dual Bcl-2/xLinhibitor that rapidly induces apoptosis in preclinical hematologic tumor models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 311.
APIM050282: AZD4320 (AZD-4320)
CAS No.: 1357576-48-7.
Molecular Formula: C45H48ClF3N4O7S3?1/2H2O.
Molecular Weight: 954.5.
Purity: 99.9-100% by Achiral and Chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, 19F-, 1H-NMRs, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.