Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
ASP3026 is A potent and selective ALK ( Anaplastic Lymphoma Kinase) inhibitor. It is more selective than Crizotinib in a kinase panel, and showed potent anti-tumor activity in an EML4-ALK driven tumor model with gatekeeper mutation while Crizotinib was ineffective even at 100 mg/gk qd (ref 1). It is currently in clinical trials.
Reference:
1. S. Kuromitsu, et al., Abstract A227: Antitumor activities of ASP3026 against EML4-ALK-dependent tumor models, Mol Cancer Ther, Nov. 2011; Volume 10, Issue 11, Supplement 1.
2. Suraj K. George, et al, The ALK inhibitor ASP3026 eradicates NPM-ALK+ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model, Oncotarget, Vol. 5, No. 14, p5750-5763.
APIM050084: ASP3026
CAS No.: 1097917-15-1.
Molecular Formula: C29H40N8O3S.
Molecular Weight: 580.74.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO and water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.