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Background Information:
AS-703026 (Pimasertib) is a potent, selective and orally bioavailable small molecular inhibitor of MEK ½ with antineoplastic activity, currently in clinical trial.
Reference:
1. Kim, K, et al, Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo, Br. J. Haematol, 2010 May; 149 (4): 537-49. Epub 2010 Mar 12.
APIM050082: AS-703026 (PIMASERTIB)
CAS No.: 1236699-92-5.
Molecular Formula: C15H15FIN3O3.
Molecular Weight: 431.2.
Purity: >99% chem and optical purity (HPLC and chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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