Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
ARS-1620 is a potent, and covalent specific inhibitor of KRAS G12C, inhibiting RAS signaling with an IC50 of 120 nM. Exhibits a half maximal G12C target engagement (TE50) at 0.3 uM and near complete engagement at 3.0 uM across a panel of cell lines harboring the mutant allele; achieves rapid and sustained in vivo target occupancy to induce tumor regression (ref. 1).
Reference:
1. M. R. Janes, et al, Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell, VOLUME 172, ISSUE 3, P578-589.E17, JAN 25, 2018.
APIM050011: ARS-1620
CAS No.: 1698055-85-4.
Molecular Formula: C21H17ClF2N4O2.
Molecular Weight: 430.8.
Purity: >99% by achiral and chiral HPLCs.
QC: Achiral and Chiral HPLCs, NMR, and Quantitative Elemental Analysis Reprort.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.