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Background Information:
ARRY-162 is a potent, orally bioavailable and non-ATP competitive inhibitor of MEK1/2 (IC50 = 12 nM ) and cellular pERK (IC50 = 11 nM) , selective against a panel of other 220 kinases (has no activity at 10 uM). It shows ex vivo inhibition of cytokine production such as IL-1, TNF and IL-6. It is currently in clinical trials.
APIM050080: ARRY-162 (BINIMETINIB, MEK162)
CAS No.: 606143-89-9.
Molecular Formula: C17H15BrF2N4O3.
Molecular Weight: 441.23.
Purity: >99.5% (HPLC).
QC: HPLC-MS, 1HNMR and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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