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Background Information:
Apremilast is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4), an enzyme that breaks down cyclic adenosine monophosphate (cAMP). In inflammatory cells, PDE4 is the dominant enzyme responsible for this reaction. The resulting increase in cAMP levels down-regulates expression of a number of the pro-inflammatory factors such as tumor necrosis factor alpha (TNFα), interleukin 17, interleukin 23, and many others, and up-regulates the anti-inflammatory interleukin 10. It is being used clinically for the treatment of certain types of psoriasis and psoriatic arthritis.
APIM050359: APREMILAST
CAS No.: 608141-41-9.
Molecular Formula: C22H24N2O7S.
Molecular Weight: 460.5.
Purity: >99.5% chemical and optical purity by HPLC and chiral HPLC.
QC: HPLC, 1H-NMR, chiral HPLC, and quantitative elemental analysis report.
Solubility: Refer to Certificate.
Storage: Refer to Certificate.
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