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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Rat IgG2a Monoclonal Antibody.
Clone: JES3-19F1.1.1.
Isotype: Rat IgG2a Kappa.
Source:The anti-human IL-10 monoclonal antibody (clone: JES3-19F1.1.1) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: JES3-19F1.1.1) specifically binds to human IL-10.
Applications:ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human IL-10 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-human IL-10 monoclonal antibody of clone JES3-19F1.1.1 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma
Vannini C, et al. Nat Cancer. 2024 Sep 5. doi: 10.1038/s43018-024-00815-0. PMID: 39215060
The anti-IL-10R antibody (clone JES3-19F1.1.1) was used to block IL-10 signaling in the tumor microenvironment of a multiple myeloma mouse model, significantly inhibiting tumor growth in combination therapy. Flow cytometry showed increased M1-like macrophage polarization, and survival curves indicated prolonged median survival compared to controls.
Tags: anti-human IL-10 JES3-19F1.1.1; anti-human IL-10 JES3-19F1.1.1 antibody
IL-10 constrains sphingolipid metabolism to limit inflammation
Harris HE, et al. Nature. 2024 Feb 21;626(7999):604-611. doi: 10.1038/s41586-024-07078-0. PMID: 38383790
The JES3-19F1.1.1 anti-IL-10R antibody, administered intraperitoneally, elevated ceramide levels in colonic tissue of colitis-induced mice. Inflammatory scores decreased with sphingolipid modulation, and gene expression profiling revealed upregulated pathways in treated animals, indicating a role in limiting inflammation.
Tags: anti-human IL-10 JES3-19F1.1.1 in vivo; anti-human IL-10 JES3-19F1.1.1 in animal model
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease
Wynn TA, et al. PLoS One. 2012 Jan 11;7(1):e30040. doi: 10.1371/journal.pone.0030040. PMID: 22291593
The JES3-19F1.1.1 antibody neutralized IL-10R during chronic Schistosoma mansoni infection in mice, leading to hepatic B cell depletion 4 weeks post-treatment. Pulmonary inflammation scores increased significantly, with histopathology showing granuloma formation in the lungs of treated mice.
Tags: anti-human IL-10 JES3-19F1.1.1 mAb in animal model; anti-human IL-10 JES3-19F1.1.1 in cancer research
IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection
Shellam GR, et al. PLoS One. 2011 Aug 25;6(8):e24500. doi: 10.1371/journal.pone.0024500. PMID: 21849677
The JES3-19F1.1.1 anti-IL-10R antibody, injected in mice infected with murine cytomegalovirus, reduced viral titers in the spleen and decreased NK cell apoptosis rates. Cytokine profiles shifted towards pro-inflammatory responses, highlighting the antibody’s role in modulating NK cell survival.
Tags: bioactivity of anti-human IL-10 JES3-19F1.1.1; anti-human IL-10 JES3-19F1.1.1 of low endotoxin
IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis
Wynn TA, et al. J Immunol. 2009 Jan 15;182(2):1150-60. doi: 10.4049/jimmunol.181.2.1150. PMID: 18981143
Combined JES3-19F1.1.1 and anti-TGF-β antibodies in acute schistosomiasis mouse models reduced liver fibrosis and mortality from 90% to 40%. Liver histopathology showed smaller granulomas in treated cohorts, demonstrating the protective role of dual IL-10R and TGF-β blockade.
Tags: anti-IL-10 (JES3-19F1.1.1) monoclonal antibody; clone JES3-19F1.1.1 of human IL-10 antibody
For more references about anti-human IL-10 antibody (JES3-19F1.1.1), please contact our scientific support team with message@sydlabs.com.
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