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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant mouse IgG2a Monoclonal Antibody.
Clone: N901.
Isotype: Mouse IgG2a kappa.
Source: The anti-human CD56 monoclonal antibody (clone: N901) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: N901) specifically binds to the human CD56 protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD56 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Background
The recombinant N901 antibody binds to the human CD56 protein, a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. CD56 is a marker of neural lineage commitment. CD56 expression is found in the hematopoietic system, natural killer cells, and other lymphoid cells, including gamma delta (γδ) Τ cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.
Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice
Bruss, C., et al. (2022). Cancers (Basel). 2022 Apr 28;14(9):2214. doi: 10.3390/cancers14092214. PMID: 35565343
The N901 antibody (anti-human CD56, PE-conjugated) was used in multiparameter flow cytometry to characterize immune cells in humanized patient-derived tumor mice. Staining was performed on spleen single-cell suspensions and peripheral blood using FACSCanto-II or Navios cytometers, with DuraClone protocols, to assess CD56 expression alongside markers like CD3, CD19, and CD45 for immune profiling.
Tags: activity of N901 antibody; function of N901 antibody
Advanced Flow Cytometry Assays for Immune Monitoring of CAR-T Cell Applications
Blache, U., et al. (2021). Front Immunol. 2021 May 3;12:658314. doi: 10.3389/fimmu.2021.658314. PMID: 34012442
The N901 antibody (anti-human CD56) was included in antibody panels (TCR, RE ALB, CAR-T1, CAR-T2, NK1, NK2) for staining EDTA blood samples in CAR-T cell immune monitoring. Flow cytometry using a DxFLEX cytometer analyzed NK cell populations, with 100 µl whole blood stained for 15 minutes to assess CD56 expression in CAR-T therapy contexts.
Tags: N901 antibody; N901 antibody for cancer research
EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes
van Dongen, J. J. M., et al. (2012). Leukemia. 2012 Sep;26(9):1908-39. doi: 10.1038/leu.2012.120. PMID: 22552007
The N901 antibody (anti-human CD56) was part of the EuroFlow antibody panels for standardized flow cytometric immunophenotyping of leukocytes. Used with EuroFlow SOPs on FACSCanto-II cytometers and Infinicyt software, it facilitated consistent analysis of CD56 expression in normal, reactive, and malignant leukocytes, supporting WHO-based diagnosis of hematological malignancies.
Tags: N901 antibody for mouse tumor model; N901 antibody mouse dose range
Detection of the CD56+/CD45- immunophenotype by flow cytometry in neuroendocrine malignancies
Bryson, G. J., et al. (2002). J Clin Pathol. 2002 Jul;55(7):535-7. doi: 10.1136/jcp.55.7.535. PMID: 12101203
The N901 antibody (anti-human CD56, PE-conjugated) was used in a three-color flow cytometry assay (with anti-CD3-FITC and anti-CD45-PECY5) on a Beckman Coulter XL cytometer to identify the CD56+/CD45− immunophenotype in neuroendocrine malignancies, such as metastatic small cell carcinoma, confirming its utility in lymphoma evaluation.
Tags: N901 mAb for animal model; N901 mAb for cancer research
Aggressive natural killer cell leukemia/lymphoma with N901-positive surface phenotype: evidence for the existence of a third lineage in lymphoid cells
Imamura, N., et al. (1988). Acta Haematol. 1988;80(3):157-64. doi: 10.1159/000205617. PMID: 2461636
The N901 antibody (anti-human CD56, NKH-1) identified CD56 expression on leukemic cells with high NK activity in aggressive NK cell leukemia/lymphoma. Flow cytometry showed these cells lacked Leu 7 (HNK-1) and T/B-cell lineage markers, confirming a distinct third lymphoid lineage without T beta, T gamma, or immunoglobulin gene rearrangement.
Tags: N901 mAb for mouse tumor model; N901 monoclonal antibody
For more references about anti-human CD56 antibody (N901), please contact our scientific support team with message@sydlabs.com.
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