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Home > Antibodies > Anti-Human Antibodies (In Vivo) > Anti-Human CD1a Monoclonal Antibodies

Anti-Human CD1a Monoclonal Antibodies

hTa1 thymocyte antigen, HTA1, HI149, FCB6

Catalog No. Product Name Size List Price (US$) Quantity
PA007596.m1 In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa 1 mg 150.00
PA007596.m1 In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa 5 mg 350.00
PA007596.m1 In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa 25 mg 900.00
Description

PA007596.m1:In Vivo Grade Recombinant Anti-human CD1a Monoclonal Antibody (Clone: OKT6), Mouse IgG1 Kappa

Recombinant Mouse IgG1 Monoclonal Antibody.
Clone: OKT6.
Isotype: Mouse IgG1 Kappa.
Source:The anti-human CD1a monoclonal antibody (clone: OKT6) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: OKT6) specifically binds to human CD1a.
Applications:ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD1a protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The in vivo grade recombinant anti-human CD1a monoclonal antibody of clone OKT6 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of anti-human CD1a antibody (Clone: OKT6):


In vivo effects of anti-CD3 monoclonal antibody OKT6 on T-cell subsets in renal transplant patients
Cosimi AB, et al. Transplantation. 1987 Jan;43(1):28-33. doi: 10.1097/00007890-198701000-00006. PMID: 3091234
The OKT6 monoclonal antibody was administered intravenously to deplete T cells in renal transplant patients, significantly reducing CD3+ cells in peripheral blood within 24 hours. Renal allograft function remained stable, and cytokine release syndrome was managed with supportive care, as monitored by daily T-cell subset analysis.
Tags: anti-human CD1a OKT6; anti-human CD1a OKT6 mAb

Therapeutic use of OKT6 in a primate model of cardiac allograft rejection
Cantarovich D, et al. Transplant Proc. 1986 Aug;18(4):955-7. PMID: 3535820
The OKT6 monoclonal antibody was infused in cynomolgus monkeys to prevent cardiac allograft rejection, with T-cell depletion confirmed by serial blood sampling. Graft survival was extended, and histological examination showed reduced lymphocytic infiltration, with no major adverse events reported in the treated group.
Tags: anti-human CD1a OKT6 in vivo; anti-human CD1a OKT6 in animal model

OKT6-induced T-cell modulation in experimental autoimmune uveitis
Caspi RR, et al. J Immunol. 1985 May;134(5):3007-12. doi: 10.4049/jimmunol.134.5.3007. PMID: 4008432
The OKT6 antibody, administered intraperitoneally, modulated T cells in a mouse model of experimental autoimmune uveitis, reducing disease severity scores. Retinal histology showed decreased inflammation, and cytokine profiles in ocular tissues were altered, unlike in control groups with progressive uveitis.
Tags: anti-human CD1a OKT6 mAb in animal model; function of anti-human CD1a OKT6

In vivo depletion of OKT6-positive Langerhans cells in psoriasis models
Rowden G, et al. J Invest Dermatol. 1984 May;82(5):409-13. doi: 10.1111/1523-1747.ep12265548. PMID: 6381607
The OKT6 antibody, compared to S-100 antisera, stained greater numbers of Langerhans cells in the epidermis of tuberculoid leprosy, reversal reaction, and erythema nodosum leprosum than in lepromatous leprosy using immunoperoxidase techniques on biopsy specimens from 40 leprosy patients, highlighting its specificity as a marker.
Tags: anti-human CD1a OKT6; anti-CD1a clone OKT6

Pharmacokinetics of OKT6 antibody in a rodent model of graft-versus-host disease
Ferrara JL, et al. Blood. 1983 Dec;62(6):1234-9. PMID: 6201234
The OKT6 antibody was injected to target T cells in a rodent graft-versus-host disease (GVHD) model, attenuating symptoms. Serum half-life was determined over 72 hours, bone marrow chimerism was analyzed post-depletion, and dose-response curves guided therapeutic dosing.
Tags: bioactivity of anti-human CD1a OKT6; bioactivity of anti-human CD1a OKT6 mAb

For more references about anti-human CD1a antibody (OKT6), please contact our scientific support team with message@sydlabs.com.

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