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Background Information:
AMG-510 is an orally available, potent and irreversible KRAS G12C inhibitor, selectively targeting the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and preventing, through a yet-to-be elucidated mechanism, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. It is currently in clinical evaluation, as both a monotherapy and in combination with other targeted and immune therapies, to treat mutated KRAS protein related solid tumors.
APIM050009: AMG-510
CAS No.: 2252403-56-6.
Molecular Formula: C30H30F2N6O3.
Molecular Weight: 560.6.
Purity: >99% by Achiral and Chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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