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Background Information:
AMG-232 (AMG 232) is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg), and is currently in clinical evaluations.
Reference:
1. D. Sun, et al, Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development, J. Med. Chem., 2014, 57 (4), pp 1454–1472.
APIM050290: AMG-232
CAS No.: 1352066-68-2.
Molecular Formula: C28H35Cl2NO5S ? 0.6Na.
Molecular Weight: 582.3.
Purity: 98.7% chemical purity (HPLC at 220 nm), 100% stereomeric purity (Chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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