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Note: Conditions of optimal aif1 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Bacground
AIF1(Allograft inflammatory factor 1), also known as IRT-1, is a protein that in humans is encoded by the AIF1 gene. This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. The gene expresses three transcripts.Using in vitro binding and coimmunoprecipitation assays, Autieri et al. (2003) determined that AIF1 interacts with actin. In unstimulated VSMCs, AIF1 colocalized with F-actin, but translocated to lamellipodia upon PDGF stimulation. VSMCs stably transduced with AIF1 retrovirus migrated 2.6-fold more rapidly in response to PDGF than control cells. AIF1 colocalized with RAC1, and AIF1-transduced VSMCs showed a constitutive and enhanced activation of RAC1. Autieri et al. (2003) concluded that AIF1 binds and polymerizes F-actin and regulates RAC1 activity and VSMC migration.
PA006506-PA1724: AIF1 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Application: WB, IHC-P.
Reactivity: Human, Rat, Mouse.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human AIF1, different from the related rat and mouse sequences by one amino acid.
Purification: Immunogen affinity purified.
Form of Antibody: lyophilized.
Storage/Stability: Stable for 1 year at -20°C and 1 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
AIF1 Proteins:
Recombinant Human AIF1 Protein
Recombinant Human AIF1 Protein
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