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Background Information:
AG-221 (Enasidenib) is a first-in-class, orally available, selective, potent inhibitor of mutant IDH2 (Isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduced 2-HG levels by >90%, reversed histone and DNA hypermethylation, and induced cellular differentiation in leukemia cell models.
APIM050312: AG-221 (ENASIDENIB)
CAS No.: 1446502-11-9.
Molecular Formula: C19H17F6N7O.
Molecular Weight: 473.4.
Purity: >99.5% by HPLC at 214 and 254 nm.
QC: HPLC-MS, 1H-NMR and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate.
Storage: Refer to Certificate.
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