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Background Information:
AG-120 (Ivosidenib) is a first-in-class, orally bioavailable, selective and potent inhibitor of mutant isocitrate dehydrogenase-1 (IDH1). Optically (enantiomerically and diastereomerically) Pure AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, blocking the formation of oncometabolite, 2-hydroxyglutarate (2HG), a substance believed to fuel cancer growth. AG-120 is currently in clinical evaluation.
APIM050311: AG-120 (IVOSIDENIB)
CAS No.: 1448347-49-6.
Molecular Formula: C28H22ClF3N6O3 ? 0.4H2O.
Molecular Weight: 590.2.
Purity: >99.8% chemically pure (achiral HPLC), 100% Optically Pure (chiral HPLC).
QC: HPLC-MS, Chiral HPLC, 1H-NMR and Quantitative Elemental Analysis.
Solubility: Refer to Certificate.
Storage: Refer to Certificate.
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