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Conditions of optimal ACTR-IIB-Fc Fusion Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background
Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Either a type I or type II receptor may initially bind ligand, followed by recruitment of its alternatetype receptor counterpart to generate a heteromeric signaling complex. Type I receptors are referred to as the Activin Receptor-like Kinases (ALKs), while the type II receptors are named for the ligands they bind. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA or ACTR-IB, and a type II receptor, ACTR-IIA or ACTR-IIB (also designated ACVR2B. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion.
BP4103: Recombinant ACTR-IIB-Fc fusion protein
Source: HEK 293 cell-derived.
Recombinant human ACTR-IIB human Fc protein is human Activin Receptor type IIB (amino acids 20-136) fused with human IgG1 Fc protein at the C-terminus.
Purity: >95% by SDS-PAGE under reducing conditions.
Formulation: 0.2 μM filtered solution of 50 mM Tris, 150 mM NaCl, pH 7.5.
Endotoxin Level: Less than 1 EU/ug of protein as determined by LAL method.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month from date of receipt, 2 to 8°C as supplied.
3 months from date of receipt, -20°C to -70°C as supplied.
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