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Background Information:
ABT-263 (Navitoclax) is a potent, selective and orally bioavailable inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, binding potently to both BCL-2 and BCL-XL with Ki values of <1 nM.
Reference:
1. Tse C et al., ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008 May 1;68(9):3421-8.
APIM050279: ABT-263 (NOVITOCLAX)
CAS No.: 923564-51-6.
Molecular Formula: C47H55ClF3N5O6S3.
Molecular Weight: 974.6.
Purity: >99% by HPLC, 100% optical purity (Chiral HPLC) *.
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis**.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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