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Background Information:
PF-06821497 (optically pure R-enantiomer) (compound 23a, Ref. 1) is a small molecule inhibitor of Histone Methyltransferase (HMT) EZH2, potently and selectively inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM). It is currently in clinical evaluation to treat lymphoma.
Reference:
1. A wrong isomer is being marketed by All other vendors (No exceptions) to date (2-28-2018).
APIM050060: PF-06821497 (PF06821497)
CAS No.: 1844849-10-0.
Molecular Formula: C22H24Cl2N2O5.
Molecular Weight: 467.3 (or refer to Certificate of Analysis, batch-specific).
Purity: >99% chem and Optical Purity by Achiral and Chiral HPLCs.
QC: Achiral HPLC-MS, Chiral HPLC, 1H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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