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Home > Chemicals > Amino Acids and Derivatives > PF-06821497 (PF06821497)

PF-06821497 (PF06821497)

PF06821497

Catalog No. Product Name Size List Price (US$) Quantity
APIM050060 PF-06821497 (PF06821497) 5 mg 175.00
APIM050060 PF-06821497 (PF06821497) 10 mg 250.00
APIM050060 PF-06821497 (PF06821497) 50 mg 875.00
Description

Background Information:

PF-06821497 (optically pure R-enantiomer) (compound 23a, Ref. 1) is a small molecule inhibitor of Histone Methyltransferase (HMT) EZH2, potently and selectively inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM). It is currently in clinical evaluation to treat lymphoma.

Reference:

1. A wrong isomer is being marketed by All other vendors (No exceptions) to date (2-28-2018).

APIM050060: PF-06821497 (PF06821497)

CAS No.: 1844849-10-0.
Molecular Formula: C22H24Cl2N2O5.
Molecular Weight: 467.3 (or refer to Certificate of Analysis, batch-specific).
Purity: >99% chem and Optical Purity by Achiral and Chiral HPLCs.
QC: Achiral HPLC-MS, Chiral HPLC, 1H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.

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